Lean Optimum » Exogenous Ketones » Dangers of Exogenous Ketones: Are They Safe?

Dangers of Exogenous Ketones: Are They Safe?

One serving of exogenous ketones contains about 8-12g of ketones/ serving, and studies show that 12g of BHB salts triple your ketone levels.

Exogenous keto supplements are extremely effective if you want to reap the benefits of a ketogenic diet without drastically reducing your carbs intake.

BHB salts retailers promise their products to help reduce symptoms of the keto flu, which include GI issues, headaches, cramps and tiredness, though the research is not yet detailed on these benefits.

But what are the side effects? Are exogenous ketones dangerous?


Exogenous ketone supplements have various toxic effects. They impact your health. They might even prove deadly if you have certain medical conditions.

Read the article below to find out more about the risks of these supplements.

Exogenous ketones are ketones produced in labs that increase your blood ketone levels artificially, mimicking ketosis so that you can lose weight, have more stamina, and a clearer head.

If you’re on this website, you must have heard about the ketogenic diet.

This diet is low in carbs and high in healthy fats and promises to help you lose weight by burning through your fat deposits your body’s primary source of energy is glucose, obtained from burning carbs.


When you restrict your carb intake, your body is forced to burn something else for energy, aka your fat stores.


Ketones are the byproduct of fat stores you burn for energy.

When you have a lot of ketones in your body, your blood ketone levels are increased, and you reach the promised land of the ketogenic diet: you are in ketosis, your metabolism is increased, you feel energetic, and you can lose weight faster.


The ketones produced in your body are called endogenous ketones, endogenous literally meaning “from the inside”.


Exogenous ketones are produced outside your body in labs, and that’s why ketone supplements are called exogenous ketones.


What’s the difference between exogenous and endogenous ketones?

There are three different types of ketones your body produces naturally:

  • Beta-hydroxybutyrate (BHB): about 78%
  • Acetoacetate: about $20
  • Acetone: 2%

Exogenous ketone supplements contain just BHBs, which are the most chemically stable and can easily be turned into pills or powders. These pills or powders contain BHB salts, meaning BHBs linked to a few minerals, such as calcium, magnesium, or sodium.


Exogenous ketones can also be linked to chemicals called esters to produce a liquid supplement. However, these types of best ketogenic supplements are mainly used for research and not retailed for general use.


Exogenous ketones have the same effects on your body as regular ketones because they increase your ketone levels artificially, so your brain thinks you’re in ketosis.

My Experience with Exogenous Ketones?

My Results

My experience taking exogenous ketones began a few years ago. I always had a hectic lifestyle, with lots of work, family, plus a ton of hobbies, and I didn’t want to give anything up.

As a result, my energy levels were plummeting every day. I heard about taking magnesium and vitamin B6 to reduce my fatigue, but it didn’t work.

Then I did some research on the ketogenic diet. At the time, I was eating ten doughnuts every day, plus pizza for lunch and dinner.

You can imagine I also gained a few extra pounds, but I was always feeling hungry, stressed and found it hard to focus.

I read plenty of exogenous ketones and decided to reduce my carbs first. I didn’t follow a strict ketogenic diet, but I stopped eating processed carbs like sugar, and I also aimed to eat healthy fats nuts, avocado, yogurt, and organic meat.

I’ll tell you more below on what ketones I took, but here’s my experience in a nutshell:

  • After the first dose of ketones, I felt more focused and had more energy.
  • After the first couple of days, my appetite decreased considerably.
  • After the first week, my sleep quality improved. Although I was still getting 6-7 hours/ night, I was waking up feeling more rested. This was when I moved on to a strict keto diet.
  • After the first month, I was feeling brave enough to go to the gym every couple of days.
  • After six weeks, I weighed myself for the first time. I was 12 pounds lighter!

I have been taking exogenous ketones ever since then, on and off for various reasons:

  • After I go to a party or eat a lot of bad carbs, to help me get back into ketosis
  • When I experience a plateau in my training 
  • When I start another bout of strict keto, which I alternate with low-carb 

The Potential Downsides of Using Exogenous Ketones

Side Effects

There are not many dangers of taking exogenous ketones, though there are some risks to consider.

Although they are proven to curb your appetite, it is not yet clear that exogenous ketones help you lose weight because:

  • Ketone supplements may interfere with fat burning, at least in theory. If your blood ketone levels are too high because you’re taking supplements, natural ketone production is halted.
  • One serving of ketones has about 50 calories, and you take several per day. If you’re not careful about restricting your caloric intake, you might ingest more calories than your body needs. 

Other side-effects include:

  1. 1
    Unknown long-term effects on your body
  2. 2
    GI distress, including nausea, cramps, and diarrhea
  3. 3
    Vitamin overdose because ketone salts provide 100% of your sodium DRV, 300% of DRV magnesium, and 150% of the DRV calcium

Any Benefits? Are Exogenous Ketones Safe?


The safety concerns on exogenous ketones regard the high intake of minerals per serving. If you’re overdosing on these supplements, you might experience severe diarrhea and dehydration, which is why you should respect the recommended dosage.

As it happened in my case and with plenty of other happy customers, exogenous ketones helped me a lot. Here are some of their reported benefits:

  • Reduced Keto Flu Symptoms
  • You Can Enter Ketosis Fast
  • Reduced Appetite With as much as 50%
  • Increased Weight Loss 
  • Improved Mental Clarity and reduced anxiety, which are beneficial effects of ketosis 

To make the most of these benefits, read the section below. Timing is as important as your dose of ketones:

When to Take Exogenous Ketones

Best Time To Take

One study showed that people who took exogenous ketones in the morning, on an empty stomach, experienced a 50% decrease in their appetite as compared to those who drank a sugary drink.

But, if you’ve eaten right before taking your ketone supplement, your blood ketone levels might not increase as much according to several studies.

Ketone supplements are more efficient in the morning or during a fast because otherwise, your body will burn the extra glucose from carbs rather than the ketones from the supplements.

You can also take exogenous ketones after a workout or before bed if you’ve recently eaten. Your ketone levels will increase to some extent, but not as much as during a fast.

Should You Use Exogenous Ketones Supplements to Put Your Body in Ketosis?

What is Ketosis

The answer was yes in my case, and I’m sure the answer is yes for most people, although there are some good Reddit controversies on the matter.

If you have diabetes, thyroid conditions, liver problems, or heart issues, talk to your GP before taking exogenous ketones. In fact, discuss this decision with your GP no matter who you are.

That said, exogenous ketones help trigger ketosis if:

  • You follow a carb-restricted diet
  • You’re taking the right dosage
  • You don’t abuse these supplements after your body is in ketosis naturally
  • You take at least one serving on an empty stomach

How to Choose a Good Exogenous Ketone Supplement

Here are some factors to take into account:

  • Fast action. Does it trigger ketosis quickly?
  • Price. Can you afford the supplement?
  • Side effects. Do people complain about side effects?
  • Where to buy and shipping. Can you find these supplements in your local Walmart? What about on Amazon? Are there discounts and coupons you can benefit from?
  • Taste and flavors. Are there enough flavors? Can you endure bad taste if the product is effective?
  • Packaging. Do you like powders that you can turn into smoothies, or do you prefer to swallow capsules quickly? Is it OK to pour powder from a box, or do you prefer separate pouches?
  • Purpose. What is this product’s unique selling proposition? Is it marketed as a fast ketosis kickstarter or is it best as a preworkout supplement?
  • Ingredients. Is this supplement clean? Does it have additional MCTs? How many calories does it have? Does it have caffeine?

Here are a few choices I tried after reading all the ketone supplement reviews I could find:

Perfect Keto Exogenous Ketones is the best overall choice because it’s certified by doctors, it increases your energy levels and focus, it eliminates hunger pangs, and it tastes great. I had no side effects with none of the Perfect Keto products, including their MCT oils and powders.

Purefit Keto (Keto BodyTone)  is a trustworthy product, which I took for a few months when I wanted to lose weight fast. This supplement comes in a convenient capsule form, it works fast, and it gave me the biggest energy boosts before my workouts. Keto BodyTone worked great after cheat meals too. But no, Purefit Keto wasn’t featured on Shark Tank!

Kiss My Keto Exogenous Ketones has different flavors and options, some of which include MCT oils. Kiss My Keto supplements trigger ketosis fast, although they don’t taste extraordinary.

Kegenix Prime Exogenous Ketones is good for speeding ketosis. I saw this product on both Reddit and Amazon. I tried it for three weeks, and it helped me lose weight, but it also gave me some nausea.

Pruvit OS promises to kickstart ketosis in about half an hour. I took these powder supplements in my morning smoothies, and I noticed they increased my focus and gave me energy. They also have some caffeine and come in a single flavor, but they helped me with my morning run.

Experiencing ketosis and ketosis-associated benefits take longer than learning about them; consequently, a mostly vegetarian diet is a more practical, if less pristine, means of providing nutrient-rich carbohydrate at a constant ketone level. These guidelines are purely cultural and are not always practical; therefore, they are tailored to allow me to live a full and healthy life while still consuming as much protein as I desire. I have not tried using animal products in this way, so please don’t use them as your guide, but be advised that meats are not the primary source of dietary carbs. People usually get their protein from fish, meat, eggs, cheese, etc. With this in mind, if you want to eat “mostly vegetarian” as a matter of principle, just remember that your body will require some carbohydrate

Perfect Keto is the best because it’s backed by research and comes with physicians’ approvals. This product tastes the best from all the supplements I tried, and it kickstarted my ketosis the fastest.

How to Take Keto Weight Loss Supplements

Follow the instructions on the label, but here are some tips to remember:


  •       Follow a low-carb diet
  •       Don’t take these supplements after you eat
  •       At least one serving should be on an empty stomach
  •       Swallow the pills with enough water
  •       Mix the powder or oil supplements in a keto-friendly smoothie
  •       Don’t go over the maximum recommended limit

The Verdict. Are Ketones Dangerous?

Ketone supplements are said to trigger ketosis, and some studies show they curb your appetite and help burn through your fat stores.

Although the research is limited in this area, there’s plenty of anecdotal evidence they work. I tried a lot of keto supplements in my day, and Perfect Keto was the best brand I found.

Their exogenous ketones helped me enter ketosis quickly, lose weight, and feel energized throughout the day.

I read a lot of positive reviews for exogenous ketones online. Although some people complain about these supplements didn’t work, my guess is most of them didn’t do their part, meaning they didn’t exercise or eat clean.

Exogenous ketones work, but they don’t do the work for you!

#1 Perfect Keto Base

Our Recommendation

  • Improves Mental Clarity
  • Zero Calories
  • Easy to Blend
  • Cuts Hunger Pangs
Perfect Keto Base